A high performance, newly-developed wire-woven bulk diamond (WBD) ventilated brake disc is introduced to reduce the operating temperatures and mass of conventional brake discs. The use of the highly porous material requires a deeper understanding of the mechanical stresses developed within a brake disc to be developed to improve the disc core strength to withstand the high stresses developed during braking. In this study, experimentally determined solid brake disc stress distribution results, separated into the compressive stresses due to the pad clamping force and the shear stresses due to the applied brake torque, were applied to the reinforcement ofthe WBD core brake disc. The analysis was based on the maximum predicted deceleration conditions of a medium sized truck (Mercedes-Benz Atego). While the WBD core material possessed sufficient strength to withstand the shearing due to the braking torque, the pad clamping load was predicted to cause disc failure. Consequently, straight radial ribs were designed to reinforce the ventilated core, with final rib dimensions of 74x14x2.5 mm, manufactured from mild steel (SAE1006). A total of 10 ribs at 36° intervals were added to reinforce the core, increasing the mass by 0.20 kg compared to the original disc. The newly reinforced WBD brake disc remains lighter than a commercially available pin-finned disc, and is expected to maintain superior thermal performance while possessing the required mechanical strength.

Glucagon-like peptide 1 (GLP-1), a kind of gut hormone, is used in the treatment of type 2 diabetes (T2D). Emerging evidence indicates that GLP-1 has anti-inflammatory activity. Chronic inflammation in the adipose tissue of obese individuals is a cause of insulin resistance and T2D. We hypothesized that GLP-1 analogue therapy in patients with T2D could suppress the inflammatory response of macrophages, and therefore inhibit insulin resistance. Our results showed that GLP-1 agonist (exendin-4) not only attenuated macrophage infiltration, but also inhibited the macrophage secretion of inflammatory cytokines including TNF-β, IL-6, and IL-1β. Furthermore, we observed that lipopolysaccharide (LPS)-induced macrophage conditioned media could impair insulin-stimulated glucose uptake. This effect was compensated by treatment with the conditioned media from macrophages treated with the combination of LPS and exendin-4. It was also observed that exendin-4 directly inhibited the activation of NF-κB in macrophages. In conclusion, our results indicated that GLP-1 improved inflammatory macrophage-derived insulin resistance by inhibiting NF-κB pathway and secretion of inflammatory cytokines in macrophages. Furthermore, our observations suggested that the anti-inflammatory effect of GLP-1 on macrophages can contribute to GLP-1 analogue therapy of T2D.

OBJECTIVE: To determine the level of understanding of the issues of climate change (CC)/variability (CV) and public health by populations of St Kitts and Nevis (SKN) and Trinidad and Tobago (T&T) and to find whether respondents would be willing to incorporate these values into strategies for dengue fever (DF) prevention. DESIGN AND METHODS: Using a cluster sampling system, representative samples of the communities of SKN (227) and T&T (650) were surveyed for responses to a questionnaire document with questions on the impact of climate variability on health, the physical environment, respondents’ willingness to utilize climate issues to predict and adapt to climate variability for DF prevention. Data were analyzed by Epi Info. RESULTS: Sixty-two per cent SKN and 55% T&T of respondents showed some understanding of the concept of climate change (CC) and distinguished this from climate variability (CV). With regard to causes of CC, 48% SKN and 50% T&T attributed CC to all of: green houses gases, holes in the ozone layer, burning of vegetation and vehicular exhaust gases. However, some 39.3% SKN and 31% (T&T) did not answer this question. In response to ranking issues of life affected by CC/CV in both countries, respondents ranked them: health > water resources > agriculture > biodiversity > coastal degradation. The major health issues identified for SKN and T&T respondents were: food-borne diseases > water-borne diseases > heat stresses; vector-borne diseases were only ranked 4th and 5th for SKN and T&T respondents respectively. There was in both countries a significant proportion of respondents (p < 0.001) who reported wet season-related increase of DF cases as a CC/CV link. Respondents identified use of environmental sanitation (ES) at appropriate times as a method of choice of using CC/CV to prevent DF outbreaks. More than 82% in both countries saw the use of the CC/CV information for DF prevention by prediction and control as strategic but only 50-51% were inclined to become personally involved. Currently, only 50% SKN and 45% T&T respondents claimed current involvement in DF vector surveillance and control in the last two days. CONCLUSION: Despite the fact that knowledge and attitudes did not always coincide with practices of using ES for DF prevention, in both countries, even with CC/CV tools of prediction being available, it seems that respondents could be persuaded to use such strategies. There is a need for demonstration of the efficacy of CC/CV information and promotion of its usefulness for community involvement in DF and possibly other disease prevention.

OBJETIVO: Determinar los niveles de comprensión de los problemas del cambio climático (CC)/ variabilidad (CV) y salud pública por parte de las poblaciones de St Kitts y Nevis (SKN) y Trinidad y Tobago (T&T), y averiguar si los encuestados estarían dispuestos a incorporar estos valores en las estrategias para la previsión de la fiebre del dengue (FD). DISEÑO Y MÉTODOS: Usando un sistema de muestreo por conglomerados, muestras representativas de las comunidades de SKN (227) y de T&T (650) fueron encuestadas mediante un cuestionario en el que se les pedía responder preguntas sobre el impacto de la variabilidad del clima sobre la salud, el ambiente físico, y la disposición de los encuestados a aprovechar las cuestiones del clima para predecir y adaptarse a la variabilidad climática a fin de prevenir la FD. Los datos fueron analizados mediante Epi Info. RESULTADOS: Sesenta y dos por ciento de los encuestados de SKN y el 55% de los de T&T, mostraron cierta comprensión del concepto de cambio climático (CC) y fueron capaces de diferenciarlo de la variabilidad climática (CV). En relación con las causas del CC, el 48% (SKN) y el 50% (T&T) atribuyó el CC a los gases de efecto invernadero, los agujeros en la capa de ozono, la quema de la vegetación, y los gases de escape de vehículos.